Tablet Making Process in Pharmaceuticals – Step by step guide

comprehensive understanding of the tablet making process in the pharmaceutical industry with this step by step guide. From selection of ingredients to inspection and packaging, this article covers all aspects of tablet production in pharma with an emphasis on quality and safety. Learn about the warnings and precautions to take …

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How to Avoid Sticking and Picking in the Tableting Industry

When a sticking defect is noticed on a tablet, one must first identify where the sticking is occurring (upper punch, lower punch or both). The location of the sticking/picking will help in identifying the root cause. There are as many causes of sticking and picking as there are formulations. A few of the most common are …

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Why is Good Tablet Design so Important and How to …

reducing the overall stroke depth of the embossing and will assist you in keeping a clear brand identity. 'Sticking' of course is another major issue in the design and manufacture of tablets. Sticking differs to picking in that it is gran ule adherence to the punch tip face, rather than in and around the embossing.

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Evaluating the effect of glidants on tablet sticking …

A sequence of blend mixers with differing quantities of glidants and constant KETP drug formulations was prepared as illustrated in Table 1.Before sifting into the V-blender, the drug and microcrystalline cellulose 102 (MCC) were sieved through a #25 mesh size, while glidants were sieved through a #40 mesh to eliminate possible lumps …

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Fixing Tableting Problems

It is generally better to run minimal upper-punch penetration (to help prevent air entrapment) and to reduce tablet ejection travel in the die bore. This practice also reduces lower punch movement, which generates heat. Heat is the enemy, because it increases sticking and picking issues.

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How to Resolve Sticking Issues in Tablet Production

Deep cup profiles can cause a softer core in the tablet which can in turn lead to sticking. It will also reduce the available space for the embossing itself; the use of a profile that is shallower, with a reduced cup depth, will allow for a larger embossing area.

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15 Common Tablet Problems and How to Address Them

Reduce granule size or optimize granulation parameters to improve the flowability of the granule. 2. ... Picking is a specific type of sticking. It occurs when the tablet material is left behind on the punch faces with embossing designs. Picking can result in tablet surface damage, incomplete tablets, or weight and appearance variations. ...

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Causes and Remedies of Sticking in Tablet Manufacturing

In this case, there are two possibilities to remedy the problem. The first remedy is to reduce the amount of binder used in the manufacturing process. Alternatively, the binder in question can also be changed so as to prevent the tablet sticking problem. Moreover, tablet sticking is also brought up by hygroscopic granular materials.

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Tableting: Industry Perspectives on Sticking During Tablet …

The manufacturing process being used will determine how many options are available to help reduce sticking. For example, a direct-compression process will have fewer processing levers to pull than a wet-granulation process. ... Angela Olsofsky, Wyatt J. Roth, and Mike Tobyn, "Sticking and picking in pharmaceutical tablet compression: An IQ ...

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Mechanical properties of powders for compaction and tableting…

High bonding indices could also indicate sticking and picking problems during tableting 14, 32. A material with a higher BI forms stronger compacts, which survive the die wall and ejection forces, whereas a material with a low BI may produce friable tablets 37. In general, the values of BI range from 0 to 0.04.

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Tablet design: Proactive ways to prevent picking and sticking

Sticking and/or picking occurs when granules or particles from the formulation attach and stick to the face of a punch cup, resulting in defective tablets. Picking is a specific type of sticking that refers to material becoming stuck on the faces of the compression tooling due to embossed designs, such as the letter or numerals of the …

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Tackling Common Problems in Tableting and Tooling

Worn tips can result in poor quality tablets and inferior embossing definition that can lead to picking and sticking. Repair should be carried out by well-trained and experienced maintenance technicians to ensure that the tooling does not exceed tolerance limits. ... thereby helping to maximize tooling life and reduce problems such as sticking ...

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How to avoid sticky situations

Keeping the temperature at a constant low level will reduce sticking. Humidity is also a problem. Moisture within a tablet can strengthen the adhesive force. This occurs with an …

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Tablet-Sticking Solutions

"We may soon find that sticking is multimechanistic, and a variety of molecular chemistry, particle, and bulk-powder characterization tools and models will be needed to parameterize the sticking mechanisms of different powders." Once these mechanisms are understood, APIs and drug products can be designed to reduce …

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The Science Behind Sticking & How To Solve It

Sticking – A Common Problem During the manufacture of tablets, two of the significant problems that are commonly encountered are sticking and picking. These two issues can often be confused with each other, however put simply, sticking is the build-up of granule on the punch tip face, and picking is when product collects within the design or

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Considerations To Alleviate Sticking And Picking …

In this article, explore how compression tooling manufacturers can identify potential sticking and picking issues before tablet and tool designs have been finalized, reducing the challenge shared by the tablet …

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Sticking and Picking in Pharmaceutical Tablet Compression: …

Sticking and picking during tablet manufacture has received increasing interest recently, as it causes tablet defects, downtime in manufacturing, and yield losses. The capricious nature of the problem means that it can appear at any stage of the development cycle, even when it has been deemed as low risk by models, tests, and …

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bjpharm.1404 British Journal of Pharmacy

defects like sticking and picking in tabletting are paramount. Tablet defects can lead to manufacturing ... improving flow and reducing sticking during tabletting. Conversely, formulas 2 to 4 utilized

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Preventing Sticking and Picking in Tablet Compression

A: Yes, atomic force microscopy can be used to analyze sticking and picking by providing detailed surface morphology and adhesion information about the tablets. Q: Is sticking and picking a common problem in tablet manufacturing? A: Yes, sticking and picking is one of the most common problems encountered in tablet …

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Reasons of tablet Sticking and Picking

Sticking and picking are two common problems which may occur during the tablet compression operation. Most of the operators and pharmacists are confused with the term sticking and picking and they use the common term sticking for all cases. But there is a big difference between sticking and picking.

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Solving Sticking and Picking Through Tablet Design

Sticking or picking issues are often not detected until transferring the product from research and development to production. Possible causes. Although sticking and picking are frequently related to deficiencies in tablet design, remediation does not always require changing the design (and thus the tools used for tablet manufacturing).

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Tableting: The Science Behind Sticking and How to Resolve It

Sticking is one of the most common problems tablet manufacturers encounter. Sticking describes the buildup of granules on the punch-tip face, which can be caused by several factors, including the formulation's physicochemical properties and the surface characteristics of the punch face. Because sticking is such a universal problem for …

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Pharmaceutical Tablets Sticking and Picking: Factors …

Generally, excessive moisture or humidity in the processing area will result in an increase in sticking or picking. Also, increasing the amount of lubricant in a formulation can improve product ...

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Solving Sticking and Picking Through Tablet Design

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The Impact of Granule Density on Tabletting and

metering in tabletting, improve uniformity in the product, and compressibility. The composition and microstructure of granular aggregates have a complex effect on granule mechanical properties, impacting tabletting and product performance. In tabletting, granule density and granule strength, affect powder re-arrangement, deformation and

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GO WITH THE FLOW – SOLVING POWDER FLOW …

tablet defects, such as sticking and picking, which may be caused by entrapped air within the tablet press die. Formulation design, engraving, tooling material or coating can improve powder flow during the compression cycle and thus reduce tablet defects. Gentle curvature in engraving cuts results in more laminar and less turbulent powder flow.

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Journal of Pharmaceutical Sciences

pharmaceutical tablets. Sticking, capping and lamination are among the defects the most commonly and the most often described in the literature. Capping and lamination both refers to a problem of tablet failure after the ejection of the tablet from the die, but they, in fact, correspond to different phenomena. Capping refers to the separation

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Characterization of Tablets with Defects Related to …

Tablets with different levels of lubricant and density were studied. Sticking of tablet material to the punches and dies during tabletting led to tablets with depressions that got worse the longer the tabletting run progressed (Figure 1). Characterization of the punch face residues suggest that most of the adherent material is API.

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Sticking and Picking in Pharmaceutical Tablet Compression: An IQ

Sticking and picking during tablet manufacture has received increasing interest recently, as it causes tablet defects, downtime in manufacturing and yield losses.

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Tablet sticking: Using a 'compression toolbox' to assess …

1. Introduction. Powder sticking is an issue for the pharmaceutical industry because the multiple mechanisms contributing to sticking are not fully understood at a fundamental, scientific level [1], [2]. 'Sticking' refers to the adhesion of the active pharmaceutical ingredient (API) or tablet excipients to the surface of the tablet punches …

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Tackling Tablet Sticking

Sticking should not be confused with picking, which can look very similar to sticking, but which can commonly be resolved by changing tablet design. In recent years, I Holland has seen increasing requests for assistance in solving sticking from both generics and pharmaceutical companies alike.

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Sticking and Picking in Pharmaceutical Tablet Compression: An IQ

Sticking and picking during tablet manufacture has received increasing interest recently, as it causes tablet defects, downtime in manufacturing, and yield losses. The capricious nature of the problem means that it can appear at any stage of the development cycle, even when it has been deemed as low risk by models, tests, and …

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Defeating Sticking and Picking of Tablets Like a Pro

In this blog post, we'll delve into the world of tableting to unravel the secrets behind sticking and picking problems. Whether you're an experienced manufacturer or just …

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